منابع مشابه
Altered expression of DJ-1 and PINK1 in sporadic ALS and in the SOD1(G93A) ALS mouse model.
Mitochondrial dysfunction is an important mechanism in the pathogenesis of neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis (ALS). DJ-1 and PTEN-induced putative kinase 1 (PINK1) are important proteins for the maintenance of mitochondrial function and protection against cell death. Mutations in the genes coding for these proteins cause familial forms of Par...
متن کاملDJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder, characterized by the degeneration of motor neurons. Oxidative stress plays a central role in the disease progression, in concert with an enhanced glutamate excitotoxicity and neuroinflammation. DJ-1 mutations, leading to the loss of functional protein, cause familial Parkinson's disease and motor neuron di...
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Panicoid grasses are major weeds of maize and sugarcane as well as of several other important grains, including sorghum, pearl millet, and foxtail millet. Pot trials were conducted to study the activity and potential interactions of topramezone in mixture with recommended rates of rimsulfuron or nicosulfuron on three annual panicoid grasses (i.e. Echinochloa oryzoides, E. phyllopogon, and Panic...
متن کاملDe Novo Mutations in Ataxin-2 Gene and ALS Risk
Pathogenic CAG repeat expansion in the ataxin-2 gene (ATXN2) is the genetic cause of spinocerebellar ataxia type 2 (SCA2). Recently, it has been associated with Parkinsonism and increased genetic risk for amyotrophic lateral sclerosis (ALS). Here we report the association of de novo mutations in ATXN2 with autosomal dominant ALS. These findings support our previous conjectures based on populati...
متن کاملMi-DJ: a multi-source intelligent DJ service
In this paper, A Multi-source intelligent DJ (Mi-DJ) service is introduced. It is an audio program platform that integrates different media types, including audio and text format content. It acts like a DJ who plays personalized audio program to user whenever and wherever users need. The audio program is automatically generated, comprising several audio clips; all of them are from either existi...
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ژورنال
عنوان ژورنال: Tijdschrift voor Taalbeheersing
سال: 2018
ISSN: 1573-9775,2352-1236
DOI: 10.5117/tvt2018.2.005.huis